Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.56 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994717 | 0.86 | HTR2A (0.64) | KDM4EHTR2AERCC1ERCC4SIGMAR1 | |
| SCHEMBL16582078 | 0.86 | ALDH1A1 (0.64) | KDM4EALDH1A1NPC1RAB9AHRH3 | |
| SCHEMBL12660139 | 0.86 | KDM4E (0.64) | KDM4EALDH1A1NPC1RAB9AHRH3 | |
| SCHEMBL5368002 | 0.86 | GAA (0.69) | KDM4EALDH1A1NPC1RAB9AHRH3 | |
| SCHEMBL4069863 | 0.85 | HTR2A (0.72) | KDM4EHTR2ACACNA1G | |
| SCHEMBL4592012 | 0.84 | KDM4E (0.63) | KDM4EALDH1A1NPC1RAB9AHRH3 | |
| SCHEMBL14174789 | 0.84 | ALDH1A1 (0.67) | KDM4EALDH1A1NPC1RAB9AHRH3 | |
| SCHEMBL518686 | 0.84 | NPC1 (0.71) | KDM4EALDH1A1NPC1RAB9AGAA | |
| SCHEMBL24274178 | 0.83 | KDM4E (0.65) | KDM4EALDH1A1HTR2ANPC1RAB9A | |
| SCHEMBL1892346 | 0.83 | ALDH1A1 (0.61) | KDM4EALDH1A1NPC1RAB9AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086462-A2 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | WYETH (US) | 2008-07-17 | — | — | WO | claimed |
| WO-2008086462-A2 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | WYETH (US) | 2008-07-17 | — | — | WO | disclosed |
| CN-1330637-A | Compounds useful in treatment of infammatory diseases | GLAXO GROUP LTD (GB) | 2002-01-09 | — | — | CN | disclosed |