SCHEMBL4739745

SCHEMBL4739745

O=C1COc2cc(F)cc(F)c21

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.39
GAA P10253 1/20 0.39
PKM P14618 2/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
RAB9A P51151 1/20 0.35
KMT2A Q03164 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HSD17B10 Q99714 1/20 0.35
TYR P14679 1/20 0.33
NR3C2 P08235 5/20 0.32
NOTUM Q6P988 1/20 0.32
MAPK14 Q16539 1/20 0.31
PKLR P30613 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23116950 0.81 KDM4E (0.41) KDM4EGAAPKMMEN1NPC1
SCHEMBL22290502 0.81 KDM4E (0.37) KDM4EGAAPKMMEN1NPC1
SCHEMBL29473475 0.81 MAOB (0.39) PKMNPC1RAB9ASMN1; SMN2TYR
SCHEMBL1429325 0.81 KDM4E (0.44) KDM4EGAAPKMMEN1NPC1
SCHEMBL1350215 0.81 MAOB (0.39) PKMNPC1RAB9ASMN1; SMN2TYR
SCHEMBL4744769 0.76
SCHEMBL1265859 0.72 NOTUM (0.47) KDM4EGAAPKMMEN1NPC1
SCHEMBL31064343 0.71 PRKCG (0.38)
SCHEMBL19312655 0.70 KDM4E (0.39) KDM4EGAAPKMMEN1NPC1
SCHEMBL1892290 0.69 FABP6 (0.54) KDM4EGAAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113584885-B Antibacterial polyester fabric and preparation method thereof 上海沙驰服饰有限公司 2022-11-25 CN claimed
US-20230348441-A1 BICYCLIC COMPOUND THAT ACTS AS CRBN PROTEIN REGULATOR MEDSHINE DISCOVERY INC. (CN) 2023-11-02 US disclosed
CN-113584885-B Antibacterial polyester fabric and preparation method thereof 上海沙驰服饰有限公司 2022-11-25 CN disclosed
CN-113584885-A Antibacterial polyester fabric and preparation method thereof 上海沙驰服饰有限公司 2021-11-02 CN disclosed
WO-2008084067-A2 PHARMACEUTICALLY ACTIVE DIHYDROBENZOFURANE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES NYCOMED GMBH (DE) 2008-07-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230348441-A1 BICYCLIC COMPOUND THAT ACTS AS CRBN PROTEIN REGULATOR CRBN, CRKL, NCOR1 KDM4E 2887/4885GAA 4139/4885PKM 3422/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.