SCHEMBL4739753

SCHEMBL4739753

O=C(CC1CCCN(S(=O)(=O)c2ccc(F)cc2)C1)NN1CCCC1

nearest known ligand 0.68

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.68
CYP2C19 P33261 1/20 0.68
MAPT P10636 4/20 0.58
KMT2A Q03164 5/20 0.56
CYP19A1 P11511 1/20 0.54
MEN1 O00255 3/20 0.52
TP53 P04637 1/20 0.52
KDM4E B2RXH2 2/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
GAA P10253 2/20 0.50
ALDH1A1 P00352 1/20 0.50
POLB P06746 1/20 0.50
DPP4 P27487 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.48
LMNA P02545 1/20 0.48
HTT P42858 1/20 0.48
PKM P14618 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4740143 0.99 CYP3A4 (0.67) CYP3A4CYP2C19MAPTKMT2ACYP19A1
SCHEMBL4738918 0.99 CYP3A4 (0.67) CYP3A4CYP2C19MAPTKMT2ACYP19A1
SCHEMBL4738947 0.92 CYP3A4 (0.64) CYP3A4CYP2C19MAPTKMT2ACYP19A1
SCHEMBL4739749 0.91 CYP3A4 (0.63) CYP3A4CYP2C19MAPTKMT2ACYP19A1
SCHEMBL4786784 0.91 CYP3A4 (0.63) CYP3A4CYP2C19MAPTKMT2ACYP19A1
SCHEMBL4737423 0.91 CYP3A4 (0.65) CYP3A4CYP2C19MAPTKMT2ACYP19A1
SCHEMBL4739834 0.90 CYP3A4 (0.61) CYP3A4CYP2C19MAPTKMT2ACYP19A1
SCHEMBL4741708 0.88 ALDH1A1 (0.56) CYP3A4CYP2C19KMT2AMEN1GAA
SCHEMBL4738964 0.87 POLB (0.51) CYP3A4CYP2C19MAPTKMT2AMEN1
SCHEMBL4736676 0.87 CYP3A4 (0.51) CYP3A4CYP2C19MAPTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008087654-A2 PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 CADILA HEALTHCARE LIMITED (IN) 2008-07-24 WO claimed
WO-2008087654-A2 PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 CADILA HEALTHCARE LIMITED (IN) 2008-07-24 WO disclosed