Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 5/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | BCL6 | P41182 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739911 | 0.79 | TYMS (0.52) | TYMSACHE | |
| SCHEMBL14148121 | 0.78 | TYMS (0.63) | TYMS | |
| SCHEMBL8261591 | 0.78 | TYMS (0.59) | TYMS | |
| SCHEMBL12391853 | 0.77 | KDR (0.51) | EGFRKDRBCL6CCNA2CDK2 | |
| SCHEMBL12391875 | 0.76 | EGFR (0.68) | EGFRKDRBRAF | |
| SCHEMBL14148437 | 0.76 | TYMS (0.56) | TYMSCCNA2CDK2 | |
| SCHEMBL12391879 | 0.76 | KDR (0.63) | EGFRKDRBCL6CCNA2CDK2 | |
| SCHEMBL4787500 | 0.70 | TYMS (0.50) | TYMS | |
| SCHEMBL12391871 | 0.69 | KDR (0.51) | EGFRKDRACHE | |
| SCHEMBL12391887 | 0.69 | EGFR (0.50) | EGFRKDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |