Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.73 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.73 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735382 | 0.90 | CHEK1 (0.58) | CHEK1CHEK2PDE4B | |
| SCHEMBL14162805 | 0.86 | CHEK1 (0.86) | CHEK1CHEK2PDE4BMAPK1USP2 | |
| SCHEMBL14163041 | 0.86 | CHEK1 (0.86) | CHEK1CHEK2PDE4BMAPK1USP2 | |
| SCHEMBL14162790 | 0.86 | CHEK1 (0.63) | CHEK1CHEK2MAPK1NPSR1 | |
| SCHEMBL4740317 | 0.86 | CHEK1 (0.53) | CHEK1CHEK2PDE4BMAPK1USP2 | |
| SCHEMBL14162946 | 0.85 | CHEK1 (0.52) | CHEK1CHEK2PDE4BMAPK1 | |
| SCHEMBL4803059 | 0.85 | CHEK1 (1.00) | CHEK1CHEK2PDE4BMAPK1USP2 | |
| SCHEMBL14162981 | 0.84 | CHEK1 (0.82) | CHEK1CHEK2PDE4BMAPK1USP2 | |
| SCHEMBL14162801 | 0.83 | CHEK1 (0.86) | CHEK1CHEK2PDE4BMAPK1USP2 | |
| SCHEMBL14162797 | 0.82 | CHEK1 (0.79) | CHEK1CHEK2PDE4BMAPK1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |