Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP1 | P63208 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14162950 | 0.86 | CHEK1 (0.38) | CHEK1CHEK2CKS1BSKP1SKP2 | |
| SCHEMBL4740157 | 0.86 | CHEK1 (0.73) | CHEK1CHEK2MAPK1USP2TP53 | |
| SCHEMBL4739614 | 0.85 | CHEK1 (0.72) | CHEK1CHEK2MAPK1USP2TP53 | |
| SCHEMBL763191 | 0.77 | CHEK1 (0.43) | CHEK1CHEK2HSD17B10ADORA3ADORA2A | |
| SCHEMBL14162790 | 0.76 | CHEK1 (0.63) | CHEK1CHEK2MAPK1CKS1BSKP1 | |
| SCHEMBL4735382 | 0.76 | CHEK1 (0.58) | CHEK1CHEK2PDE4BCKS1BSKP1 | |
| SCHEMBL753721 | 0.75 | HPGD (0.47) | CHEK1CHEK2CKS1BSKP1SKP2 | |
| SCHEMBL14162946 | 0.72 | CHEK1 (0.52) | CHEK1CHEK2MAPK1PDE4BCKS1B | |
| SCHEMBL14162993 | 0.72 | CHEK1 (0.37) | CHEK1CHEK2CKS1BSKP1SKP2 | |
| SCHEMBL14163053 | 0.71 | CHEK1 (0.68) | CHEK1CHEK2MAPK1USP2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |