Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 2/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4679568 | 0.85 | STAT3 (0.42) | PTGS2PTGDR2DHODHGAAALDH1A1 | |
| SCHEMBL4676256 | 0.75 | CDH1 (0.57) | PTGDR2DHODHGAAALDH1A1CYP1A2 | |
| SCHEMBL5234243 | 0.72 | CNR1 (0.55) | DHODHGAACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL24987817 | 0.71 | DHODH (0.47) | PTGDR2DHODHALDH1A1STAT3STAT1 | |
| SCHEMBL28871750 | 0.70 | TLR7 (0.74) | TRPV1 | |
| SCHEMBL2468818 | 0.69 | PLAU (0.49) | PTGDR2DHODHALDH1A1STAT3STAT1 | |
| SCHEMBL4677623 | 0.68 | DHODH (0.52) | PTGDR2DHODHGAAALDH1A1CYP1A2 | |
| SCHEMBL31417745 | 0.67 | HDAC4 (0.62) | PTGS2 | |
| SCHEMBL1978109 | 0.67 | EPHX2 (0.57) | DHODHGAAALDH1A1TRPV1 | |
| SCHEMBL212982 | 0.67 | DHODH (0.43) | PTGDR2DHODHALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638953-B1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | claimed |