Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737132 | 0.82 | MAPK14 (0.44) | MAPK14PDK1HDAC11HDAC6HSP90AA1 | |
| SCHEMBL4785417 | 0.81 | CACNA1H (0.41) | MAPK14LMNAPDK1HSP90AA1HSP90AB1 | |
| SCHEMBL4737668 | 0.81 | GAA (0.56) | MAPK14PDK1HDAC11HDAC6HDAC8 | |
| SCHEMBL4738913 | 0.78 | MAOB (0.40) | MAPK14LMNACACNA2D1 | |
| SCHEMBL8193274 | 0.77 | MAPK14 (0.42) | MAPK14LMNAPDK1HSP90AA1CXCR2 | |
| SCHEMBL4734905 | 0.77 | HDAC3 (0.40) | — | |
| SCHEMBL4737347 | 0.76 | DRD4 (0.43) | MAPK14LMNACXCR2 | |
| SCHEMBL4735156 | 0.75 | KCNH2 (0.39) | MAPK14LMNAPDK1HSP90AA1HSP90AB1 | |
| SCHEMBL4735318 | 0.75 | OPRM1 (0.37) | MAPK14CXCR2CACNA2D1 | |
| SCHEMBL4733936 | 0.73 | OPRM1 (0.49) | CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |