Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.65 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | PLCD1 | P51178 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | IDE | P14735 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.55 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26490546 | 0.99 | TDP1 (0.64) | TDP1PKMPLCD1MEN1ABL1 | |
| SCHEMBL15482071 | 0.99 | TDP1 (0.64) | TDP1PKMPLCD1MEN1ABL1 | |
| SCHEMBL10277136 | 0.99 | TDP1 (0.64) | TDP1PKMPLCD1MEN1ABL1 | |
| SCHEMBL13049575 | 0.99 | TDP1 (0.64) | TDP1PKMPLCD1MEN1ABL1 | |
| SCHEMBL7936987 | 0.99 | TDP1 (0.64) | TDP1PKMPLCD1MEN1ABL1 | |
| SCHEMBL4904852 | 0.99 | TDP1 (0.64) | TDP1PKMPLCD1MEN1ABL1 | |
| SCHEMBL20042594 | 0.98 | TDP1 (0.62) | TDP1PKMPLCD1MEN1ABL1 | |
| SCHEMBL20711508 | 0.98 | TDP1 (0.62) | TDP1PKMPLCD1MEN1ABL1 | |
| SCHEMBL31135781 | 0.97 | TDP1 (0.61) | TDP1PKMPLCD1MEN1ABL1 | |
| SCHEMBL31135784 | 0.97 | TDP1 (0.61) | TDP1PKMPLCD1MEN1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089485-A2 | CARBOXYETHYLPYRROLE COMPOUNDS AND METHODS OF THEIR PRODUCTION | THE CLEVELAND CLINIC FOUNDATION (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008089487-A2 | CARBOXYETHYLPYRROLE COMPOUNDS AND METHODS OF THEIR PRODUCTION | THE CLEVELAND CLINIC FOUNDATION (US) | 2008-07-24 | — | — | WO | disclosed |