Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.52 |
| ▸ | PPARG | P37231 | 7/20 | 0.52 |
| ▸ | PPARD | Q03181 | 7/20 | 0.52 |
| ▸ | PPARA | Q07869 | 7/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TLR2 | O60603 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.52 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL4901036 | 1.00 | GPR84 (0.52) | GPR84PPARGPPARDPPARAHDAC11 | |
| Butyric Acid SCHEMBL3043683 | 1.00 | GPR84 (0.52) | GPR84PPARGPPARDPPARAHDAC11 | |
| Butyric Acid SCHEMBL6923796 | 1.00 | GPR84 (0.52) | GPR84PPARGPPARDPPARAHDAC11 | |
| Butyric Acid SCHEMBL2817305 | 1.00 | GPR84 (0.52) | GPR84PPARGPPARDPPARAHDAC11 | |
| Butyric Acid SCHEMBL5479989 | 0.95 | GPR84 (0.47) | GPR84PPARGPPARDPPARAHDAC11 | |
| Butyric Acid SCHEMBL10452438 | 0.95 | GPR84 (0.47) | GPR84PPARGPPARDPPARAHDAC11 | |
| Palmitic Acid SCHEMBL30142631 | 0.93 | GPR84 (0.63) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL4900334 | 0.93 | GPR84 (0.57) | GPR84PPARGPPARDPPARAHDAC11 | |
| Decanoic Acid SCHEMBL9956867 | 0.93 | GPR84 (0.63) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL573131 | 0.93 | GPR84 (0.63) | GPR84PPARGPPARDPPARAHDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045836-B1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2008-03-05 | — | — | EP | disclosed |
| US-6284768-B1 | Src family SH2 domain inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | disclosed |
| US-6268365-B1 | Src family SH2 domain inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-07-31 | — | — | US | disclosed |
| EP-1045836-A1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-6054470-A | Src family SH2 domain inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-04-25 | — | — | US | disclosed |
| WO-1999031066-A1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |
| US-5830863-A | NATURALLY OCCURRING NEUROKININ A WITH MODIFIED AMIDE BOND CONNECTING THE TWO AMINO ACIDS ON THE CARBOXY TERMINAL | MERRELL PHARMACEUTICALS INC. (US) | 1998-11-03 | — | — | US | disclosed |
| US-5731286-A | Cyclic neurokinin A antagonists | MERRELL PHARMACEUTICALS, INC. (US) | 1998-03-24 | — | — | US | disclosed |
| EP-0412542-B1 | Cyclic neurokinin antagonists | MERRELL DOW PHARMA (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0347802-B1 | Neurokinin A antagonists | MERRELL DOW PHARMA (US) | 1994-06-15 | — | — | EP | disclosed |
| EP-0412542-A2 | Cyclic neurokinin antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-02-13 | — | — | EP | disclosed |
| EP-0347802-A2 | Neurokinin A antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-12-27 | — | — | EP | disclosed |