Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.39 |
| ▸ | MTOR | P42345 | 5/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787508 | 0.93 | PIK3CD (0.44) | PIK3CDPIK3CAMTORCCR2BRAF | |
| SCHEMBL4738329 | 0.92 | PIK3CA (0.42) | PIK3CDPIK3CAMTORCCR2BRAF | |
| SCHEMBL4740778 | 0.92 | CCR2 (0.39) | PIK3CDPIK3CAMTORCCR2BRAF | |
| SCHEMBL4739014 | 0.90 | PI4KA (0.42) | PIK3CDPIK3CAMTORCCR2BRAF | |
| SCHEMBL14148281 | 0.89 | PIK3CA (0.48) | PIK3CDPIK3CAMTORCCR2BRAF | |
| SCHEMBL4737748 | 0.89 | PIK3C3 (0.42) | PIK3CDPIK3CAMTORBRAFPIK3C3 | |
| SCHEMBL4787518 | 0.88 | CCR2 (0.41) | PIK3CDPIK3CAMTORCCR2BRAF | |
| SCHEMBL4740239 | 0.88 | PIK3CA (0.45) | PIK3CDPIK3CAMTORBRAFPIK3CG | |
| SCHEMBL4741753 | 0.87 | CCR2 (0.42) | PIK3CDPIK3CAMTORCCR2BRAF | |
| SCHEMBL4736805 | 0.86 | PIK3CD (0.39) | PIK3CDPIK3CAMTORCCR2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |