Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609212 | 0.81 | SLC6A4 (0.39) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL31444592 | 0.80 | TACR1 (0.46) | HTR2CHTR2BHTR2AGRIN2BOPRM1 | |
| SCHEMBL22040130 | 0.80 | TACR1 (0.46) | HTR2CHTR2BHTR2AGRIN2BOPRM1 | |
| SCHEMBL25355557 | 0.80 | HTR2C (0.54) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL1638122 | 0.80 | HTR2C (0.54) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL28776903 | 0.80 | HTR2C (0.54) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL28205555 | 0.79 | KMT2A (0.40) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL5566775 | 0.76 | HTR2C (0.54) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL25355022 | 0.76 | HTR2A (0.48) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL25238033 | 0.76 | HTR2A (0.48) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828125-B1 | ARYLPIPERAZINE DERIVATIVES AND THEIR USE AS LIGANGS SELECTIVE OF THE DOPAMINE D3 RECEPTOR | BIOPROJET SOC CIV (FR) | 2008-04-09 | — | — | EP | disclosed |
| EP-1828125-A1 | ARYLPIPERAZINE DERIVATIVES AND THEIR USE AS LIGANGS SELECTIVE OF THE DOPAMINE D3 RECEPTOR | BIOPROJET (FR) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006058993-A1 | ARYLPIPERAZINE DERIVATIVES AND THEIR USE AS LIGANDS SELECTIVE OF THE DOPAMINE D3 RECEPTOR | BIOPROJET (FR) | 2006-06-08 | — | — | WO | disclosed |