SCHEMBL474131

SCHEMBL474131

Nc1ccc(OCc2ccccc2)cc1C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 2/20 0.57
NR4A1 P22736 1/20 0.57
NR4A3 Q92570 1/20 0.57
MAOB P27338 3/20 0.56
MCL1 Q07820 2/20 0.56
CTSV O60911 1/20 0.56
CTSL P07711 1/20 0.56
MEN1 O00255 1/20 0.55
KMT2A Q03164 1/20 0.55
SLC16A3 O15427 1/20 0.54
PARP10 Q53GL7 1/20 0.54
SMN1; SMN2 Q16637 2/20 0.53
ALDH1A1 P00352 2/20 0.53
HPGD P15428 1/20 0.53
MDH2 P40926 1/20 0.53
GAA P10253 1/20 0.53
MAPT P10636 1/20 0.53
MAOA P21397 1/20 0.53
RAB9A P51151 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4930554 0.89 PARP10 (0.60) NR4A2NR4A1NR4A3MAOBMEN1
SCHEMBL5377638 0.88 SRD5A2 (0.58) NR4A2NR4A1NR4A3MAOBMEN1
SCHEMBL5495792 0.88 MAOB (0.60) NR4A2NR4A1NR4A3MAOBMCL1
SCHEMBL22762675 0.87 MRGPRX4 (0.58) MAOBMEN1KMT2ASLC16A3ALDH1A1
SCHEMBL15589447 0.85 MAOB (0.51) NR4A2NR4A1NR4A3MAOBMCL1
SCHEMBL136203 0.85 ALDH1A1 (0.56) MAOBCTSVCTSLPARP10SMN1; SMN2
SCHEMBL7161222 0.85 MAOB (0.65) NR4A2NR4A1NR4A3MAOBMCL1
SCHEMBL5065166 0.84 MAOB (0.53) NR4A2NR4A1NR4A3MAOBMEN1
SCHEMBL28134459 0.83 MEN1 (0.62) MAOBMEN1KMT2AALDH1A1MAPT
SCHEMBL15589445 0.83 MAOB (0.56) NR4A2NR4A1NR4A3MAOBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992016509-A1 MULTISUBSTITUTED 1-HYDROXY-9-ACRIDONES WITH ANTICANCER ACTIVITY SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1992-10-01 WO claimed
CN-115448877-A Fused ring pyridone derivative and application thereof 杭州百诚医药科技股份有限公司 2022-12-09 CN disclosed
EP-2205593-B1 QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF SANOFI SA (FR) 2016-01-13 EP disclosed
EP-2416777-B1 THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES SANOFI SA (FR) 2014-11-12 EP disclosed
EP-2411009-B1 Therapeutic uses of quinazolinedione derivatives SANOFI SA (FR) 2013-03-20 EP disclosed
EP-2416777-A1 THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES SANOFI (FR) 2012-02-15 EP disclosed
EP-2411009-A1 THERAPEUTIC USES OF QUINAZOLINEDIONE DERIVATIVES SANOFI (FR) 2012-02-01 EP disclosed
EP-1957481-B1 PYRROLIDIN(THI)ONES HETEROCYCLICALLY SUBSTITUTED IN 3-POSITION GRUENENTHAL GMBH (DE) 2011-03-02 EP disclosed
WO-2010116090-A1 THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES SANOFI-AVENTIS (FR) 2010-10-14 WO disclosed
WO-2010109148-A1 THERAPEUTIC USES OF QUINAZOLINEDIONE DERIVATIVES SANOFI-AVENTIS (FR) 2010-09-30 WO disclosed
WO-2000061195-A1 BENZODIAZEPINE DERIVATIVES FOR IMAGING THROMBI DIATIDE, INC. (US) 2000-10-19 WO disclosed
US-5382572-A Viricides SCHERING CORPORATION (US) 1995-01-17 US disclosed
US-5378694-A Herpes viricide, hypotensive agent SCHERING CORPORATION (US) 1995-01-03 US disclosed
US-5296602-A Condensing substituted ortho-halo- or ortho-aminobenzoic acid with meta-halo- or meta-aminoanisole, cyclizing, N-alkylating, de-O-methylating SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1994-03-22 US disclosed
EP-0550464-A1 ANTIVIRAL COMPOUNDS AND ANTIHYPERTENSIVE COMPOUNDS SCHERING CORPORATION (US) 1993-07-14 EP disclosed
EP-0547145-A1 ANTIVIRAL 2(1H)-QUINOLINONE COMPOUNDS SCHERING CORPORATION (US) 1993-06-23 EP disclosed
US-5179093-A Viricides SCHERING CORPORATION (US) 1993-01-12 US disclosed
WO-1992016509-A1 MULTISUBSTITUTED 1-HYDROXY-9-ACRIDONES WITH ANTICANCER ACTIVITY SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1992-10-01 WO disclosed
WO-1992004328-A1 ANTIVIRAL COMPOUNDS AND ANTIHYPERTENSIVE COMPOUNDS SCHERING CORPORATION (US) 1992-03-19 WO disclosed
WO-1992004326-A1 ANTIVIRAL COMPOUNDS SCHERING CORPORATION (US) 1992-03-19 WO disclosed