Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY1 | Q08828 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787849 | 0.88 | ADCY1 (0.49) | ADCY1TP53PTGS1TRPV1 | |
| SCHEMBL4259960 | 0.84 | SMO (0.66) | ADCY1LMNAALDH1A1ADCY8KCNK3 | |
| SCHEMBL4737638 | 0.84 | KDR (0.55) | LMNAALDH1A1GAAMAPT | |
| SCHEMBL14148561 | 0.83 | TP53 (0.50) | ADCY1ALDH1A1TP53MAPT | |
| SCHEMBL14148500 | 0.82 | ADORA1 (0.62) | LMNAALDH1A1KCNK3MAPT | |
| SCHEMBL7744086 | 0.80 | KDR (0.51) | ADCY1ALDH1A1TP53P2RX1 | |
| SCHEMBL14148491 | 0.80 | KDM4E (0.66) | ADCY1LMNAKCNK3TP53THRB | |
| SCHEMBL7744087 | 0.79 | KDR (0.46) | ADCY1LMNAALDH1A1KCNK3TP53 | |
| SCHEMBL20598167 | 0.79 | ADCY1 (1.00) | ADCY1LMNAALDH1A1ADCY8TP53 | |
| SCHEMBL4740831 | 0.78 | SMN1; SMN2 (0.62) | ADCY1LMNAALDH1A1ADCY8GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |