Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741773 | 1.00 | PIK3CD (0.46) | PIK3CDUSP30PIK3CAGPR119PIK3CB | |
| SCHEMBL4742866 | 1.00 | PIK3CD (0.46) | PIK3CDUSP30PIK3CAGPR119PIK3CB | |
| SCHEMBL4745261 | 0.94 | CHEK2 (0.49) | PIK3CDUSP30CHEK2PDE4B | |
| SCHEMBL4745263 | 0.94 | CHEK2 (0.49) | PIK3CDUSP30CHEK2PDE4B | |
| SCHEMBL14127666 | 0.94 | GPR119 (0.51) | GPR119CHEK2PRMT5PDE4B | |
| SCHEMBL29686325 | 0.87 | PIK3CD (0.49) | PIK3CDUSP30PIK3CAGPR119PIK3CB | |
| SCHEMBL7466564 | 0.84 | PIK3CD (0.49) | PIK3CDUSP30PIK3CAGPR119PIK3CB | |
| SCHEMBL5548078 | 0.84 | GPR119 (0.55) | PIK3CDUSP30PIK3CAGPR119PIK3CB | |
| SCHEMBL28716248 | 0.84 | GPR119 (0.55) | PIK3CDUSP30PIK3CAGPR119PIK3CB | |
| SCHEMBL5548878 | 0.84 | GPR119 (0.55) | PIK3CDUSP30PIK3CAGPR119PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008109613-A1 | BENZO[C][2,7]NAPHTHYRIDINE DERIVATIVES, AND THEIR USE AS KINASE INHIBITORS | WYETH (US) | 2008-09-12 | — | — | WO | disclosed |