Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 8/20 | 0.74 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | PRKCA | P17252 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4799398 | 0.88 | FADS1 (0.74) | FADS1GRM4TRPA1EGFRCDK1 | |
| SCHEMBL4785286 | 0.85 | FADS1 (1.00) | FADS1GRM4TRPA1EGFRSRC | |
| SCHEMBL4796579 | 0.83 | FADS1 (1.00) | FADS1GRM4TRPA1EGFRSRC | |
| SCHEMBL4741654 | 0.81 | FADS1 (1.00) | FADS1GRM4TRPA1EGFRCDK1 | |
| SCHEMBL4787290 | 0.81 | FADS1 (1.00) | FADS1GRM4TRPA1EGFRABL1 | |
| SCHEMBL4783364 | 0.81 | FADS1 (0.80) | FADS1GRM4TRPA1EGFRCDK1 | |
| SCHEMBL4783454 | 0.80 | FADS1 (1.00) | FADS1GRM4TRPA1EGFRABL1 | |
| SCHEMBL4742110 | 0.78 | FADS1 (0.74) | FADS1GRM4TRPA1SYK | |
| SCHEMBL4811755 | 0.78 | FADS1 (0.74) | FADS1GRM4TRPA1EGFRPLK4 | |
| SCHEMBL4787382 | 0.78 | FADS1 (1.00) | FADS1GRM4EGFRCDK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089307-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |