Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.70 |
| ▸ | EGFR | P00533 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | APP | P05067 | 1/20 | 0.70 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.69 |
| ▸ | CCNC | P24863 | 1/20 | 0.67 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.67 |
| ▸ | CDK8 | P49336 | 1/20 | 0.67 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.67 |
| ▸ | CNR1 | P21554 | 1/20 | 0.62 |
| ▸ | CNR2 | P34972 | 1/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.62 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13283269 | 0.85 | HTT (0.76) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL9921509 | 0.84 | PIK3CD (0.85) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL13192080 | 0.84 | HTT (0.70) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL13912334 | 0.84 | EGFR (0.76) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL8497590 | 0.83 | APP (1.00) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL18733232 | 0.82 | HTT (1.00) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL13191858 | 0.82 | HTT (1.00) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL18103414 | 0.82 | PIK3CD (0.62) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL13191857 | 0.81 | HTT (0.76) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL29383948 | 0.81 | CCNC (1.00) | HTTEGFRMAPK1LMNAAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101535279-B | Quinazoline based egfr inhibitors containing a zinc binding moiety | CURIS INC | 2015-05-20 | — | — | CN | disclosed |
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |