Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | EGFR | P00533 | 2/20 | 0.70 |
| ▸ | APP | P05067 | 1/20 | 0.70 |
| ▸ | CCNC | P24863 | 3/20 | 0.67 |
| ▸ | CDK8 | P49336 | 3/20 | 0.67 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.67 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.67 |
| ▸ | CNR1 | P21554 | 1/20 | 0.62 |
| ▸ | CNR2 | P34972 | 1/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.62 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1734678 | 0.86 | LMNA (0.72) | HTTMAPK1LMNAEGFRNR2F2 | |
| SCHEMBL13283269 | 0.85 | HTT (0.76) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL9921509 | 0.84 | PIK3CD (0.85) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL13912334 | 0.84 | EGFR (0.76) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL4741967 | 0.84 | HTT (0.70) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL8497590 | 0.83 | APP (1.00) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL7411782 | 0.82 | HTT (0.52) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL16172718 | 0.81 | CCNC (1.00) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL29383948 | 0.81 | CCNC (1.00) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL1585442 | 0.80 | LMNA (0.71) | HTTLMNAEGFRCCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295716-A | Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors | 麦克尼斯迪克治疗有限公司 | 2023-12-26 | — | — | CN | disclosed |
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | ATG7, BECN1, SQSTM1 | HTT 4078/4885MAPK1 310/4885LMNA 3469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.