Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.53 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 5/20 | 0.51 |
| ▸ | HTR2C | P28335 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27895777 | 0.91 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL14624766 | 0.85 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL9303072 | 0.85 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL14132272 | 0.84 | HTR2A (0.72) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL19563418 | 0.83 | ALDH1A1 (0.71) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL4159760 | 0.83 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL14625270 | 0.83 | HTR2A (0.76) | ALDH1A1GAAL3MBTL1HTR2AHTR2C | |
| SCHEMBL23884744 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL12188831 | 0.81 | HTR2A (0.72) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL12169379 | 0.81 | HTR2A (0.72) | ALDH1A1KMT2AMEN1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008109007-A1 | BRIDGED PHENANTHRIDINES | CARA THERAPEUTICS, INC. (US) | 2008-09-12 | — | — | WO | disclosed |
| US-20080214537-A1 | BRIDGED PHENANTHRIDINES | CARA THERAPEUTICS, INC. (US) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214537-A1 | BRIDGED PHENANTHRIDINES | CNR2, TRPV1, CNR1 | ALDH1A1 4403/4885KMT2A 1600/4885MEN1 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.