Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689627 | 0.86 | THRB (0.46) | THRBTHRAKMT2AKDM4EALDH1A1 | |
| SCHEMBL4687865 | 0.84 | SMN1; SMN2 (0.44) | THRBTHRAKMT2AKDM4EALDH1A1 | |
| SCHEMBL4689621 | 0.83 | PARP1 (0.46) | THRBTHRAKMT2AKDM4EALDH1A1 | |
| SCHEMBL13617723 | 0.82 | THRB (0.65) | THRBTHRAKMT2ALMNA | |
| SCHEMBL1786513 | 0.80 | SIRT2 (0.42) | KDM4EALDH1A1LMNASMN1; SMN2SIRT2 | |
| SCHEMBL1180075 | 0.77 | KDM4E (0.62) | KMT2AKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6808017 | 0.76 | ESR1 (0.48) | THRBTHRAKMT2AKDM4EALDH1A1 | |
| SCHEMBL9198133 | 0.76 | SIRT2 (0.51) | THRBTHRAKMT2AKDM4EALDH1A1 | |
| SCHEMBL25597478 | 0.76 | PARP1 (0.47) | KMT2AKDM4EALDH1A1LMNAPARP15 | |
| SCHEMBL30983963 | 0.75 | TDP1 (0.46) | KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008096093-A1 | OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES | ARGENTA DISCOVERY LTD. (GB) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008096093-A1 | OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES | ARGENTA DISCOVERY LTD. (GB) | 2008-08-14 | — | — | WO | disclosed |