Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | USP9X | Q93008 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13350411 | 0.83 | CYP3A4 (0.46) | SMN1; SMN2LMNAKDM4EKCNA5CTSA | |
| SCHEMBL6821878 | 0.81 | CFTR (0.40) | SMN1; SMN2LMNAKCNA5HPGDGAA | |
| SCHEMBL3998595 | 0.81 | CTSA (0.40) | CTSA | |
| SCHEMBL4001991 | 0.81 | HPGD (0.45) | KCNA5CTSAHPGD | |
| SCHEMBL4005492 | 0.80 | CTSA (0.43) | KCNA5CTSA | |
| SCHEMBL6115561 | 0.78 | MAPT (0.43) | SMN1; SMN2KDM4EKCNA5 | |
| SCHEMBL4009328 | 0.78 | CTSA (0.42) | LMNACTSAGAAAOC3ALDH1A1 | |
| SCHEMBL1803210 | 0.77 | DPP4 (0.38) | CTSAHPGDS | |
| SCHEMBL20773271 | 0.77 | CTSA (0.39) | CTSAHPGDS | |
| SCHEMBL4004965 | 0.77 | TSHR (0.38) | SMN1; SMN2LMNAKDM4EKCNA5CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493297-B1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK SHARP & DOHME (US) | 2016-08-17 | — | — | EP | disclosed |
| EP-2112206-B1 | Polymer Composition | ROHM & HAAS (US) | 2016-06-29 | — | — | EP | disclosed |
| EP-2166043-B1 | Thickener composition and method for thickening aqueous systems | ROHM & HAAS (US) | 2016-04-27 | — | — | EP | disclosed |
| US-9181181-B2 | 2-substituted-3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease | ALBIREO AB (SE) | 2015-11-10 | — | — | US | disclosed |
| US-8987310-B2 | Heterocycle amide T-type calcium channel antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-03-24 | — | — | US | disclosed |
| US-20140303175-A1 | 2-Substituted-3-Phenylpropionic Acid Derivatives and Their Use in the Treatment of Inflammatory Bowel Disease | ALBIREO AB (SE) | 2014-10-09 | — | — | US | disclosed |
| US-8785681-B2 | 2-substituted-3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease | ALBIREO AB (SE) | 2014-07-22 | — | — | US | disclosed |
| US-20120202852-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK SHARP & DOHME LLC | 2012-08-09 | — | — | US | disclosed |
| US-20120129870-A1 | PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-24 | — | — | US | disclosed |
| EP-2166044-B1 | Thickened compositions and method for thickening aqueous polymer compositions | ROHM & HAAS (US) | 2012-02-01 | — | — | EP | disclosed |
| US-7741402-B2 | Thickener composition and method for thickening aqueous systems | ROHM AND HAAS COMPANY (US) | 2010-06-22 | — | — | US | disclosed |
| US-20100076145-A1 | Thickener composition and method for thickening aqueous systems | ROHM AND HAAS COMPANY | 2010-03-25 | — | — | US | disclosed |
| EP-2166044-A1 | Thickened compositions and method for thickening aqueous polymer compositions | Rohm and Haas Company (US) | 2010-03-24 | — | — | EP | disclosed |
| EP-2166043-A2 | Thickener composition and method for thickening aqueous systems | Rohm and Haas Company (US) | 2010-03-24 | — | — | EP | disclosed |
| EP-2125711-A1 | 2 -SUBSTITUTED- 3 -PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | Albireo Ab (SE) | 2009-12-02 | — | — | EP | disclosed |
| EP-2112206-A1 | Polymer Composition | Rohm and Haas Company (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009079597-A1 | PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-06-25 | — | — | WO | disclosed |
| US-20080234411-A1 | Thickener composition and method for thickening aqueous systems | ROHM AND HAAS COMPANY | 2008-09-25 | — | — | US | disclosed |
| EP-1972665-A2 | Thickener composition and method for thickening aqueous systems | Rohm and Haas Company (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2008108735-A1 | 2 -SUBSTITUTED- 3 -PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | ALBIREO AB (SE) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202852-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | CACNA1G, CACNA1H, CACNA1I | SMN1; SMN2 2668/4885LMNA 2206/4885KDM4E 3538/4885 |
| US-20120129870-A1 | PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR | NPY2R, NPY1R, NPY5R | SMN1; SMN2 3545/4885LMNA 3751/4885KDM4E 4085/4885 |
| US-20140303175-A1 | 2-Substituted-3-Phenylpropionic Acid Derivatives and Their Use in the Treatment of Inflammatory Bowel Disease | TPMT, FABP2, PTGES3 | SMN1; SMN2 2799/4885LMNA 4572/4885KDM4E 1332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.