Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649164 | 0.84 | MEN1 (0.72) | GAAHSD17B10MEN1KMT2AADORA2B | |
| SCHEMBL4649176 | 0.80 | ADORA2B (0.61) | GAAHSD17B10MEN1KMT2AADORA2B | |
| SCHEMBL10113142 | 0.78 | TSHR (0.73) | GAAHSD17B10MEN1KMT2AADORA2B | |
| SCHEMBL4648858 | 0.77 | GAA (0.66) | GAAHSD17B10ADORA2BTSHRALDH1A1 | |
| SCHEMBL10113448 | 0.74 | POLB (0.72) | GAAMEN1KMT2AADORA2BATM | |
| SCHEMBL4647287 | 0.73 | GAA (0.84) | GAAHSD17B10MEN1KMT2AADORA2B | |
| SCHEMBL4647892 | 0.73 | GAA (0.70) | GAAHSD17B10MEN1KMT2AADORA2B | |
| SCHEMBL10113469 | 0.71 | GAA (0.66) | GAAHSD17B10ADORA2BTSHRPOLB | |
| SCHEMBL19752708 | 0.71 | MEN1 (0.79) | HSD17B10MEN1KMT2AADORA2BTSHR | |
| SCHEMBL5343069 | 0.71 | MEN1 (0.79) | HSD17B10MEN1KMT2AADORA2BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675834-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1675834-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037799-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |