Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743629 | 0.99 | SMN1; SMN2 (0.39) | MCHR1SERPINE1MEN1LMNAKMT2A | |
| SCHEMBL7518369 | 0.93 | CA9 (0.40) | MEN1LMNAKMT2ASMN1; SMN2KEAP1 | |
| SCHEMBL7518492 | 0.90 | TSHR (0.39) | SERPINE1MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL7522692 | 0.88 | CA12 (0.38) | KMT2ASMN1; SMN2KEAP1NFE2L2CA1 | |
| SCHEMBL5963054 | 0.88 | TSHR (0.40) | SERPINE1MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL14080627 | 0.87 | KMT2A (0.41) | SERPINE1MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL14080566 | 0.87 | KMT2A (0.41) | SERPINE1MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL14080613 | 0.87 | KMT2A (0.41) | SERPINE1MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL7513482 | 0.86 | CA12 (0.41) | SERPINE1MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL14080720 | 0.85 | CNR2 (0.41) | SERPINE1MEN1LMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112251-A1 | CYCLOPROPYL-CONTAINING POLYAMINE ANALOGS AS DISEASE THERAPIES | PROGEN PHARMACEUTICALS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |