Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14080566 | 0.98 | KMT2A (0.41) | CNR2KDM4ESERPINE1CA1CA2 | |
| SCHEMBL14080613 | 0.98 | KMT2A (0.41) | CNR2KDM4ESERPINE1CA1CA2 | |
| SCHEMBL14080627 | 0.98 | KMT2A (0.41) | CNR2KDM4ESERPINE1CA1CA2 | |
| SCHEMBL7509603 | 0.92 | CA1 (0.41) | CNR2KDM4ESERPINE1CA1CA2 | |
| SCHEMBL7509594 | 0.92 | CA1 (0.41) | CNR2KDM4ESERPINE1CA1CA2 | |
| SCHEMBL7518577 | 0.92 | CA1 (0.41) | CNR2KDM4ESERPINE1CA1CA2 | |
| SCHEMBL7516875 | 0.91 | CA2 (0.38) | CNR2KDM4ESERPINE1CA1CA2 | |
| SCHEMBL5963054 | 0.88 | TSHR (0.40) | KDM4ESERPINE1CA1CA2MMP1 | |
| SCHEMBL4743601 | 0.88 | F2 (0.38) | KDM4ESERPINE1CA1CA2MMP1 | |
| SCHEMBL4744059 | 0.87 | KMT2A (0.35) | CNR2KDM4EKMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414154-B2 | Polyamine compounds and compositions for use in conjunction with cancer therapy | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-08-19 | — | — | US | disclosed |
| US-7314959-B2 | Amino thiol compounds and compositions for use in conjunction with cancer therapy | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-01-01 | — | — | US | disclosed |