⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7957510 | 0.98 | — | — | |
| SCHEMBL5924432 | 0.82 | — | — | |
| SCHEMBL18955199 | 0.78 | — | — | |
| SCHEMBL474833 | 0.77 | KCNH2 (0.46) | — | |
| SCHEMBL3319227 | 0.77 | KDM4E (0.35) | — | |
| SCHEMBL9460184 | 0.76 | — | — | |
| SCHEMBL1452385 | 0.76 | — | — | |
| SCHEMBL16579802 | 0.76 | BACE1 (0.33) | — | |
| SCHEMBL3321022 | 0.76 | CYP2D6 (0.34) | — | |
| SCHEMBL3318837 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099668-B1 | 5-BIPHENYL-4-HETEROARYLCARBONYLAMINO-PENTANOIC ACID DERIVATIVES AS NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2022-05-04 | — | — | EP | disclosed |
| US-9815794-B2 | Inhibition of bacterial biofilms and microbial growth with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2017-11-14 | — | — | US | disclosed |
| US-9783507-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-10-10 | — | — | US | disclosed |
| US-20170137388-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-05-18 | — | — | US | disclosed |
| US-20160194288-A1 | INHIBITION OF BACTERIAL BIOFILMS AND MICROBIAL GROWTH WITH IMIDAZOLE DERIVATIVES | UNIV NORTH CAROLINA STATE (US) | 2016-07-07 | — | — | US | disclosed |
| US-9295257-B2 | Inhibition of bacterial biofilms and microbial growth with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2016-03-29 | — | — | US | disclosed |
| WO-2015116786-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-06 | — | — | WO | disclosed |
| US-20140023691-A1 | INHIBITION OF BACTERIAL BIOFILMS AND MICROBIAL GROWTH WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-01-23 | — | — | US | disclosed |
| US-20110294780-A1 | SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-a MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-12-01 | — | — | US | disclosed |
| WO-2008090357-A2 | N, N; -SUBSTITUTED PIPERAZINES BINDING TO MELANOCORTIN RECEPTOR | PALATIN TECHNOLOGIES, INC. (US) | 2008-07-31 | — | — | WO | disclosed |
| EP-0693072-B9 | METHOD FOR THE SYNTHESIS OF 4- AND/OR 5-(DI)SUBSTITUTED 2-AMINOIMIDAZOLES FROM 2-AMINOIMIDAZOLES AND ALDEHYDES | UNIV COLUMBIA (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-0693072-B1 | METHOD FOR THE SYNTHESIS OF 4- AND/OR 5-(DI)SUBSTITUTED 2-AMINOIMIDAZOLES FROM 2-AMINOIMIDAZOLES AND ALDEHYDES | UNIV COLUMBIA (US) | 2003-12-03 | — | — | EP | disclosed |
| US-6218549-B1 | KETAL AMINOIMIDAZOLE COMPOUND AND A N-(2-FORMYLETHYL)PYRROLE-2-CARBOXAMIDE; PREPARATION; METABOLITES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2001-04-17 | — | — | US | disclosed |
| US-6103899-A | Bicyclic aminoimidazoles | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2000-08-15 | — | — | US | disclosed |
| US-5834609-A | Bicyclic aminoimidazoles | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1998-11-10 | — | — | US | disclosed |
| EP-0693072-A4 | METHOD FOR THE SYNTHESIS OF 4- AND/OR 5-(DI)SUBSTITUTED 2-AMINOIMIDAZOLES FROM 2-AMINOIMIDAZOLES AND ALDEHYDES | UNIV COLUMBIA (US) | 1997-09-24 | — | — | EP | disclosed |
| EP-0693072-A1 | METHOD FOR THE SYNTHESIS OF 4- AND/OR 5-(DI)SUBSTITUTED 2-AMINOIMIDAZOLES FROM 2-AMINOIMIDAZOLES AND ALDEHYDES | The Trustees of Columbia University in the City of New York (US) | 1996-01-24 | — | — | EP | disclosed |
| WO-1994024136-A1 | METHOD FOR THE SYNTHESIS OF 4- AND/OR 5-(DI)SUBSTITUTED 2-AMINOIMIDAZOLES FROM 2-AMINOIMIDAZOLES AND ALDEHYDES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1994-10-27 | — | — | WO | disclosed |
| US-5358960-A | Stabilization of protein; aging resistance | THE ROCKEFELLER UNIVERSITY (US) | 1994-10-25 | — | — | US | disclosed |
| US-4761460-A | SOLUBLE IN LOW-BOILING SOLVENTS, CURABLE | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1988-08-02 | — | — | US | disclosed |