Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.37 |
| ▸ | HTR2A | P28223 | 8/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743917 | 0.92 | SLC6A2 (0.37) | SLC6A2HTR2AHDAC3HDAC4HDAC1 | |
| SCHEMBL4740844 | 0.79 | SLC6A2 (0.60) | SLC6A2HTR2APKM | |
| SCHEMBL3567564 | 0.78 | SLC6A2 (0.44) | SLC6A2HTR2AHDAC3HDAC4HDAC1 | |
| SCHEMBL14469423 | 0.78 | SLC6A2 (0.48) | SLC6A2HTR2AHDAC3HDAC4HDAC1 | |
| SCHEMBL3572358 | 0.76 | SLC6A2 (0.56) | SLC6A2HTR2AHDAC3HDAC4HDAC1 | |
| SCHEMBL3569687 | 0.75 | SLC6A2 (0.60) | SLC6A2HTR2AHDAC3HDAC4HDAC1 | |
| SCHEMBL3579618 | 0.75 | HTR2A (0.59) | SLC6A2HTR2AHTR1AHTR1B | |
| Hydrochloric Acid SCHEMBL3574473 | 0.75 | SLC6A2 (0.55) | SLC6A2HTR2AHDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL3579549 | 0.74 | HTR2A (0.58) | SLC6A2HTR2AHTR1AHTR1B | |
| SCHEMBL3567511 | 0.73 | HTR2A (0.60) | SLC6A2HTR2AHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973876-A2 | SULFONYL SUBSTITUTED 1H-INDOLES AS LIGANDS FOR THE 5-HYDROXYTRYPTAMINE RECEPTORS | Wyeth (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007084841-A2 | SULFONYL SUBSTITUTED 1H-INDOLES AS LIGANDS FOR THE 5-HYDROXYTRYPTAMINE RECEPTORS | WYETH (US) | 2007-07-26 | — | — | WO | disclosed |