Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.50 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.49 |
| ▸ | F3 | P13726 | 1/20 | 0.49 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3059074 | 0.86 | PLOD2 (0.59) | PLOD2NPC1RAB9AALDH1A1APP | |
| SCHEMBL360711 | 0.86 | PLOD2 (0.69) | PLOD2NPC1RAB9AALDH1A1APP | |
| SCHEMBL2511934 | 0.85 | KMT2A (0.55) | PLOD2NPC1RAB9AALDH1A1APP | |
| SCHEMBL11825208 | 0.85 | TSHR (0.62) | PLOD2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL2662937 | 0.85 | GAA (0.57) | PLOD2ALDH1A1APPGAAHCAR3 | |
| SCHEMBL5424552 | 0.85 | MAPT (0.57) | PLOD2NPC1RAB9AALDH1A1APP | |
| SCHEMBL29861055 | 0.85 | KMT2A (0.55) | PLOD2NPC1RAB9AALDH1A1APP | |
| Hydrochloric Acid SCHEMBL11169565 | 0.85 | PLOD2 (0.67) | PLOD2NPC1RAB9AALDH1A1APP | |
| Bromide SCHEMBL11040809 | 0.85 | PLOD2 (0.67) | PLOD2NPC1RAB9AALDH1A1APP | |
| SCHEMBL31326722 | 0.84 | NAPRT (0.65) | PLOD2NPC1RAB9AALDH1A1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115141-A1 | 4, 5-DIHYDRO-1,3-THIAZOL-2-AMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-09-25 | — | — | WO | disclosed |