Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.83 |
| ▸ | RXRA | P19793 | 2/20 | 0.73 |
| ▸ | RARG | P13631 | 1/20 | 0.73 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.53 |
| ▸ | PPARA | Q07869 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rosiglitazone SCHEMBL11957687 | 0.91 | PPARG (1.00) | PPARGRXRARARGESR1FFAR1 | |
| Rosiglitazone SCHEMBL29530259 | 0.91 | PPARG (1.00) | PPARGRXRARARGESR1FFAR1 | |
| Rosiglitazone SCHEMBL5169 | 0.91 | PPARG (1.00) | PPARGRXRARARGESR1FFAR1 | |
| Rosiglitazone SCHEMBL2355017 | 0.91 | PPARG (1.00) | PPARGRXRARARGESR1FFAR1 | |
| Rosiglitazone SCHEMBL7052472 | 0.91 | PPARG (1.00) | PPARGRXRARARGESR1FFAR1 | |
| Rosiglitazone SCHEMBL5468691 | 0.90 | PPARG (0.98) | PPARGRXRARARGESR1FFAR1 | |
| SCHEMBL13246974 | 0.90 | PPARG (0.90) | PPARGRXRARARGESR1FFAR1 | |
| Rosiglitazone SCHEMBL3377103 | 0.90 | PPARG (0.98) | PPARGRXRARARGESR1FFAR1 | |
| Rosiglitazone SCHEMBL1489117 | 0.90 | PPARG (0.98) | PPARGRXRARARGESR1FFAR1 | |
| Rosiglitazone SCHEMBL6976956 | 0.90 | PPARG (0.98) | PPARGRXRARARGESR1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756099-B1 | SYNTHESIS OF ANTIDIABETIC ROSIGLITAZONE DERIVATIVES | CIPLA LTD (IN) | 2008-11-12 | — | — | EP | disclosed |