Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rosiglitazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 15/20 | 0.98 |
| ▸ | RXRA | P19793 | 2/20 | 0.86 |
| ▸ | RARG | P13631 | 1/20 | 0.86 |
| ▸ | PPARA | Q07869 | 2/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rosiglitazone SCHEMBL29530259 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL11957687 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL2355017 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL7052472 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL5169 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL3381790 | 0.98 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL3377103 | 0.98 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL6976956 | 0.98 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL1489117 | 0.98 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL3375739 | 0.98 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185167-A1 | SODIUM SALTS OF 5-[4-[2-(N-METHYL-N-(2-PYRIDYL)AMINO)ETHOXY]BENZYL]THIAZOLIDINE-2,4-DIONE | SMITHKLINE BEECHAM P.L.C. | 2007-08-09 | — | — | US | claimed |
| EP-1813612-A1 | SODIUM SALTS OF 5-[4-[2-(N-METHYL-N-(2-PYRIDYL)AMINO)ETHOXY]B ENZYL]THIAZOLIDINE-2,4-DIONE | SMITHKLINE BEECHAM PLC (GB) | 2007-08-01 | — | — | EP | claimed |
| CN-1883476-A | Orally administered medicinal composition for treating diabetes | HENAN FUREN PHARMACEUTICAL GRO (CN) | 2006-12-27 | — | — | CN | claimed |
| US-20060004058-A1 | Sodium salts of 5-'4-'2-(N-methyl-N-(2-pyridyl) amino) ethoxy!benzyl!thiazolidine -2, 4-dione | SMITHKLINE BEECHAM PLC | 2006-01-05 | — | — | US | claimed |
| US-20050277679-A9 | Sodium salts of 5-'4-'2-(N-methyl-N-(2-pyridyl)amino)ethoxy!benzyl!thiazolidine-2, 4-dione | SMITHKLINE BEECHAM P.L.C. | 2005-12-15 | — | — | US | claimed |
| US-20040214866-A1 | Sodium salts of 5-'4-'2-(N-methyl-N-(2-pyridyl)amino)ethoxy!benzyl!thiazolidine-2, 4-dione | SMITHKLINE BEECHAM P.L.C. | 2004-10-28 | — | — | US | claimed |
| US-20040014752-A1 | Sodium salts of 5-[4-]2-(n-methyl-N-(2-pyridyl) ethoxy]benzyl]thiazolidine-2,4-dione | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-01-22 | — | — | US | claimed |
| EP-1332142-A1 | SODIUM SALTS OF 5-[4-[2-(N-METHYL-N-(2-PYRIDYL)AMINO)ETHOXY]B ENZYL]THIAZOLIDINE-2,4-DIONE | SmithKline Beecham p.l.c. (GB) | 2003-08-06 | — | — | EP | claimed |
| WO-2002026735-A1 | SODIUM SALTS OF 5-'4-'2-(N-METHYL-N-(2-PYRIDYL)AMINO)ETHOXY]BENZYL]THIAZOLIDINE-2,4-DIONE | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-04-04 | — | — | WO | claimed |
| CN-117279681-A | Product delivery device and method | 呼吸解决方案股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-116018131-A | Fast orodispersible tablet with inner cavity | 阿普雷奇亚制药有限责任公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-114821572-B | Deep learning oral pill identification method based on multi-view and data expansion | 德阳市人民医院 | 2023-04-21 | — | — | CN | disclosed |
| CN-113081991-B | Pharmaceutical dosage forms and uses thereof | 南京三迭纪医药科技有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-110290781-A | The dosage form of stomach and intestine privileged site control release | 南京三迭纪医药科技有限公司 | 2019-09-27 | — | — | CN | disclosed |
| US-20050277679-A9 | Sodium salts of 5-'4-'2-(N-methyl-N-(2-pyridyl)amino)ethoxy!benzyl!thiazolidine-2, 4-dione | SMITHKLINE BEECHAM P.L.C. | 2005-12-15 | — | — | US | disclosed |
| US-20040214866-A1 | Sodium salts of 5-'4-'2-(N-methyl-N-(2-pyridyl)amino)ethoxy!benzyl!thiazolidine-2, 4-dione | SMITHKLINE BEECHAM P.L.C. | 2004-10-28 | — | — | US | disclosed |
| US-20040014752-A1 | Sodium salts of 5-[4-]2-(n-methyl-N-(2-pyridyl) ethoxy]benzyl]thiazolidine-2,4-dione | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-01-22 | — | — | US | disclosed |
| CN-1466585-A | Sodium salt of 5- [ 4- [ 2- (N-methyl-N- (2-pyridyl) amino) ethoxy ] benzyl ] thiazolidine-2, 4-dione | ʷ | 2004-01-07 | — | — | CN | disclosed |
| EP-1332142-A1 | SODIUM SALTS OF 5-[4-[2-(N-METHYL-N-(2-PYRIDYL)AMINO)ETHOXY]B ENZYL]THIAZOLIDINE-2,4-DIONE | SmithKline Beecham p.l.c. (GB) | 2003-08-06 | — | — | EP | disclosed |
| WO-2002026735-A1 | SODIUM SALTS OF 5-'4-'2-(N-METHYL-N-(2-PYRIDYL)AMINO)ETHOXY]BENZYL]THIAZOLIDINE-2,4-DIONE | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-04-04 | — | — | WO | disclosed |