Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | CETP | P11597 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL43074 | 0.93 | HDAC3 (0.69) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL13972908 | 0.92 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL13703413 | 0.91 | HDAC3 (0.71) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL13588433 | 0.89 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL16669873 | 0.82 | ALDH1A1 (0.67) | ALDH1A1GAAPOLBRXFP1HDAC3 | |
| SCHEMBL3335404 | 0.81 | HDAC1 (0.84) | SMN1; SMN2KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL13003435 | 0.81 | TSHR (0.65) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL13204287 | 0.81 | TSHR (0.58) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL10114769 | 0.81 | TSHR (0.58) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL10114312 | 0.81 | TSHR (0.58) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008099165-A1 | PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | WO | disclosed |