Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.69 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3339347 | 0.90 | HTR6 (0.63) | HTR6DRD2 | |
| SCHEMBL4676436 | 0.82 | HTR6 (1.00) | HTR6DRD2CYP3A4CYP2D6 | |
| SCHEMBL3342638 | 0.80 | HTR6 (0.66) | HTR6 | |
| SCHEMBL3335694 | 0.78 | HTR6 (0.58) | HTR6 | |
| SCHEMBL3340082 | 0.77 | HTR6 (0.68) | HTR6 | |
| SCHEMBL3340018 | 0.77 | HTR6 (0.46) | HTR6 | |
| SCHEMBL3338538 | 0.76 | HTR6 (0.83) | HTR6DRD2 | |
| SCHEMBL4673875 | 0.76 | HTR6 (1.00) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL5473805 | 0.76 | HTR6 (0.87) | HTR6DRD2CYP3A4CYP2D6 | |
| SCHEMBL3336465 | 0.76 | HTR6 (0.74) | HTR6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984351-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | Memory Pharmaceuticals Corporation (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007098418-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-08-30 | — | — | WO | disclosed |