Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 11/20 | 0.58 |
| ▸ | MEN1 | O00255 | 9/20 | 0.58 |
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.58 |
| ▸ | MMP14 | P50281 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14041269 | 1.00 | KMT2A (0.58) | KMT2AMEN1MAPTL3MBTL1NPSR1 | |
| SCHEMBL12924705 | 0.88 | KMT2A (0.67) | KMT2AMEN1MAPTL3MBTL1NPSR1 | |
| SCHEMBL14198801 | 0.88 | KMT2A (0.67) | KMT2AMEN1MAPTL3MBTL1NPSR1 | |
| SCHEMBL4746375 | 0.82 | KMT2A (0.62) | KMT2AMEN1MAPTL3MBTL1NPSR1 | |
| SCHEMBL4746370 | 0.82 | KMT2A (0.62) | KMT2AMEN1MAPTL3MBTL1NPSR1 | |
| SCHEMBL4748813 | 0.80 | KMT2A (0.60) | KMT2AMEN1MAPTL3MBTL1NPSR1 | |
| SCHEMBL14041425 | 0.80 | KMT2A (0.60) | KMT2AMEN1MAPTL3MBTL1NPSR1 | |
| SCHEMBL14041333 | 0.79 | KMT2A (0.57) | KMT2AMEN1MAPTL3MBTL1NPSR1 | |
| SCHEMBL5706419 | 0.78 | KAT8 (0.71) | KMT2AMEN1MAPTL3MBTL1NPSR1 | |
| SCHEMBL5706420 | 0.78 | KAT8 (0.71) | KMT2AMEN1MAPTL3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008121861-A2 | PYRAZOLE AND PYRROLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-10-09 | — | — | WO | claimed |
| WO-2008121861-A2 | PYRAZOLE AND PYRROLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-10-09 | — | — | WO | disclosed |