Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949205 | 0.83 | NPC1 (0.42) | SLC6A3SLC6A4MAOBCYP2D6 | |
| SCHEMBL4950357 | 0.78 | ACHE (0.37) | SLC6A3SLC6A4MAOBCYP2D6ACHE | |
| SCHEMBL4139579 | 0.77 | CYP2D6 (0.43) | SLC6A3SLC6A4MAOBCYP2D6DRD2 | |
| SCHEMBL4947552 | 0.75 | CYP2D6 (0.39) | SLC6A3SLC6A4MAOBCYP2D6ACHE | |
| SCHEMBL4152111 | 0.74 | GRM2 (0.58) | DRD2 | |
| SCHEMBL4750908 | 0.72 | MAOB (0.38) | SLC6A3SLC6A4MAOBCYP2D6ACHE | |
| SCHEMBL4949797 | 0.72 | ACHE (0.38) | SLC6A3SLC6A4MAOBCYP2D6ACHE | |
| SCHEMBL4161960 | 0.71 | ACHE (0.47) | MAOBACHEDRD2HTR2AHTR2C | |
| SCHEMBL4147399 | 0.71 | MAOB (0.46) | SLC6A3SLC6A4MAOBACHEDRD2 | |
| SCHEMBL23696355 | 0.70 | SSTR5 (0.61) | SLC6A3SLC6A4CYP2D6DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912989-A2 | TRICYCLIC BENZIMIDAZOLES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2008-04-23 | — | — | EP | claimed |
| WO-2007018998-A2 | TRICYCLIC BENZIMIDAZOLES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | WO | claimed |