Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606031 | 0.93 | ALDH1A1 (0.55) | HDAC1HDAC2BRD4EPHX2ALDH1A1 | |
| SCHEMBL14247337 | 0.88 | USP30 (0.56) | HDAC1HDAC2BRD4ALDH1A1NPC1 | |
| SCHEMBL15342507 | 0.88 | USP30 (0.56) | HDAC1HDAC2BRD4ALDH1A1NPC1 | |
| SCHEMBL15342512 | 0.88 | USP30 (0.56) | HDAC1HDAC2BRD4ALDH1A1NPC1 | |
| SCHEMBL4746559 | 0.87 | HDAC1 (0.48) | HDAC1HDAC2EPHX2ALDH1A1NPC1 | |
| SCHEMBL29847380 | 0.86 | HDAC1 (0.48) | HDAC1HDAC2BRD4ALDH1A1NPC1 | |
| SCHEMBL29847387 | 0.86 | HDAC1 (0.48) | HDAC1HDAC2BRD4ALDH1A1NPC1 | |
| SCHEMBL18928571 | 0.85 | USP30 (0.53) | HDAC1HDAC2BRD4ALDH1A1NPC1 | |
| SCHEMBL28580589 | 0.85 | USP30 (0.53) | HDAC1HDAC2BRD4ALDH1A1NPC1 | |
| SCHEMBL16895642 | 0.85 | USP30 (0.50) | HDAC1HDAC2BRD4EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119712-A1 | BENZOIMIDAZOLE DERIVATIVES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008119712-A1 | BENZOIMIDAZOLE DERIVATIVES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |