SCHEMBL4746202

SCHEMBL4746202

CN(C)C(=O)CN1CCN(CCCCCOc2ccc(C(=O)c3ccc(Cl)cc3)c(O)c2)CC1

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAOB P27338 20/20 0.54
MAOA P21397 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4746681 0.90 HRH3 (0.46) MAOBMAOA
SCHEMBL4746694 0.90 LSS (0.55) MAOB
SCHEMBL4743286 0.89 DRD2 (0.48)
SCHEMBL4743300 0.88 HRH3 (0.57)
SCHEMBL4746760 0.84 HRH3 (0.51)
SCHEMBL4747494 0.83 HRH3 (0.46)
SCHEMBL4745404 0.82 F10 (0.49)
SCHEMBL4746206 0.80 HRH3 (0.57)
SCHEMBL4744711 0.79 HRH3 (0.56)
SCHEMBL4745363 0.79 HRH3 (0.56)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008107320-A1 PIPERIDINE AND PIPERAZINE DERIVATIVES USED AS ANTI-NEOPLASIC AGENTS OR CELL PROLIFERATION INHIBITORS CEREP (FR) 2008-09-12 WO disclosed