Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.32 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.32 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL718611 | 0.87 | APP (0.42) | FFAR1APP | |
| SCHEMBL7717366 | 0.84 | GRM5 (0.50) | GRM5FFAR1CA1CA2CA7 | |
| SCHEMBL10300106 | 0.84 | GRM5 (0.50) | GRM5FFAR1CA1CA2CA7 | |
| SCHEMBL718949 | 0.84 | GRM5 (0.50) | GRM5FFAR1CA1CA2CA7 | |
| Charcoal, Activated SCHEMBL31286307 | 0.81 | GRM5 (0.48) | GRM5FFAR1CA1CA2CA7 | |
| Fluoride SCHEMBL31286313 | 0.81 | GRM5 (0.48) | GRM5FFAR1CA1CA2CA7 | |
| SCHEMBL989900 | 0.80 | GRM5 (0.39) | GRM5FFAR1CA1CA2CA7 | |
| SCHEMBL20212084 | 0.77 | GRM5 (0.50) | GRM5FFAR1CA1CA2CA7 | |
| SCHEMBL13810534 | 0.77 | GRM5 (0.45) | GRM5FFAR1CA1CA2CA7 | |
| SCHEMBL10300061 | 0.76 | GRM5 (0.50) | GRM5FFAR1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651621-B1 | 2- (QUINOXALIN-5-YLSULFONYLAMINO) -BENZAMIDE COMPOUNDS AS CCK2 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-06 | — | — | EP | claimed |