Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 14/20 | 0.56 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648961 | 0.85 | CXCR2 (0.58) | CXCR2CXCR1CYP2C9KMT2AMEN1 | |
| SCHEMBL18953433 | 0.81 | CXCR2 (0.40) | CXCR2KMT2AMEN1KDM4EMAPT | |
| SCHEMBL4648882 | 0.78 | CXCR2 (0.64) | CXCR2CXCR1CYP2C9KMT2AMEN1 | |
| SCHEMBL5955072 | 0.78 | CXCR2 (0.47) | CXCR2CXCR1CYP2C9 | |
| SCHEMBL18953514 | 0.77 | CXCR2 (0.46) | CXCR2CXCR1CYP2C9KMT2AKDM4E | |
| SCHEMBL18953337 | 0.74 | CXCR2 (0.44) | CXCR2CXCR1CYP2C9KMT2AKDM4E | |
| SCHEMBL18953524 | 0.74 | CXCR2 (0.44) | CXCR2CXCR1CYP2C9KMT2AKDM4E | |
| SCHEMBL18953362 | 0.73 | CXCR2 (0.43) | CXCR2CXCR1KMT2AMEN1KDM4E | |
| SCHEMBL18953469 | 0.73 | CXCR2 (0.59) | CXCR2CXCR1CYP2C9 | |
| SCHEMBL18953471 | 0.73 | CXCR2 (0.59) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631559-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1631559-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2005000231-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | disclosed |