Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estrone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 2/20 | 0.97 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.97 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.97 |
| ▸ | STS | P08842 | 6/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.97 |
| ▸ | MAPT | P10636 | 2/20 | 0.97 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.97 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.97 |
| ▸ | SHBG | P04278 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
| ▸ | PGR | P06401 | 1/20 | 0.97 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | AR | P10275 | 1/20 | 0.97 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.97 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.97 |
| ▸ | SNCA | P37840 | 1/20 | 0.97 |
| ▸ | HTR2B | P41595 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estrone SCHEMBL5553656 | 1.00 | CYP19A1 (0.97) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL29621709 | 0.99 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL31398229 | 0.99 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL29373834 | 0.99 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL12054811 | 0.99 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL157262 | 0.99 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL5028951 | 0.99 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL15079288 | 0.99 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL12822081 | 0.99 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL7831317 | 0.99 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721348-A1 | MONOGLYCERIDE/LACTATE ESTER PERMEATION ENHANCER | ALZA CORPORATION (US) | 1996-07-17 | — | — | EP | claimed |
| WO-1995009006-A1 | MONOGLYCERIDE/LACTATE ESTER PERMEATION ENHANCER | ALZA CORPORATION (US) | 1995-04-06 | — | — | WO | claimed |
| CN-104569439-B | The test strips of colloidal gold chromatography detection ESTRONE SODIUM SULFATE | 新疆医科大学第附属医院 | 2016-06-22 | — | — | CN | disclosed |
| CN-104824370-A | Pregnant mare feed and feeding method thereof | INST OF FEED XINJIANG ACADEMY OF ANIMAL SCIENCE | 2015-08-12 | — | — | CN | disclosed |
| CN-103415286-A | Compounds and methods for treating pain | AKRON MOLECULES GMBH | 2013-11-27 | — | — | CN | disclosed |
| CN-102335181-A | Composite medicinal preparation containing conjugated estrogens | NANJING TEFENG PHARMACEUTICAL CO LTD | 2012-02-01 | — | — | CN | disclosed |
| WO-2008130616-A2 | DIARYL MORPHOLINES AS CB1 MODULATORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |
| CN-100421652-C | Conjugated estrogen pharmaceutical composition and application method thereof | DURAMED PHARMACEUTICALS INC (US) | 2008-10-01 | — | — | CN | disclosed |
| EP-1784192-A2 | VAGINAL CREAM COMPOSITIONS, KITS THEREOF AND METHODS OF USING THEREOF | Duramed Pharmaceuticals, Inc. (US) | 2007-05-16 | — | — | EP | disclosed |
| EP-1581156-A4 | GILSONITE DERIVED PHARMACEUTICAL DELIVERY COMPOSITIONS AND METHODS | DPC PRODUCTS INC (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006023496-A2 | VAGINAL CREAM COMPOSITIONS, KITS THEREOF AND METHODS OF USING THEREOF | DURAMED PHARMACEUTICALS, INC. (US) | 2006-03-02 | — | — | WO | disclosed |
| CN-1230163-C | 2-phenyl-1- [4- (2-aminoethoxy) -benzyl ] -indole in combination with an estrogen | AMERICAN HOME PROD (US) | 2005-12-07 | — | — | CN | disclosed |
| EP-1581156-A2 | GILSONITE DERIVED PHARMACEUTICAL DELIVERY COMPOSITIONS AND METHODS | DPC Products, Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004062628-A2 | GILSONITE DERIVED PHARMACEUTICAL DELIVERY COMPOSITIONS AND METHODS | DPC PRODUCTS, INC. (US) | 2004-07-29 | — | — | WO | disclosed |
| CN-1403157-A | Method for treating female sexual dysfunction and evaluating compound for treating female sexual dysfunction | PFIZER PROD INC (US) | 2003-03-19 | — | — | CN | disclosed |
| CN-1326347-A | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens | AMERICAN HOME PROD (US) | 2001-12-12 | — | — | CN | disclosed |
| CN-1309637-A | Compositions comprising 2-phenyl-indole compounds and estrogen formutations | AMERICAN HOME PROD (US) | 2001-08-22 | — | — | CN | disclosed |
| CN-1197387-A | Pharmaceutical compsns. of conjugated estrogens and methods for their use | DURAMED PHARMACEUTICALS INC (US) | 1998-10-28 | — | — | CN | disclosed |