Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | PARP1 | P09874 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CDC25A | P30304 | 2/20 | 0.45 |
| ▸ | CDC25B | P30305 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747422 | 1.00 | LMNA (0.58) | LMNAMAPTKDM4ESMN1; SMN2PARP1 | |
| SCHEMBL4747413 | 1.00 | LMNA (0.58) | LMNAMAPTKDM4ESMN1; SMN2PARP1 | |
| SCHEMBL4750422 | 0.90 | PARP1 (0.61) | LMNAMAPTKDM4ESMN1; SMN2PARP1 | |
| SCHEMBL4750420 | 0.90 | PARP1 (0.61) | LMNAMAPTKDM4ESMN1; SMN2PARP1 | |
| SCHEMBL4750427 | 0.90 | PARP1 (0.61) | LMNAMAPTKDM4ESMN1; SMN2PARP1 | |
| SCHEMBL4749670 | 0.86 | MAPT (0.58) | LMNAMAPTKDM4ESMN1; SMN2PARP1 | |
| SCHEMBL4749669 | 0.86 | MAPT (0.58) | LMNAMAPTKDM4ESMN1; SMN2PARP1 | |
| SCHEMBL4749668 | 0.86 | MAPT (0.58) | LMNAMAPTKDM4ESMN1; SMN2PARP1 | |
| SCHEMBL4750380 | 0.86 | MAPT (0.58) | LMNAMAPTKDM4ESMN1; SMN2PARP1 | |
| SCHEMBL4750376 | 0.86 | MAPT (0.58) | LMNAMAPTKDM4ESMN1; SMN2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |