Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 8/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.49 |
| ▸ | KIT | P10721 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749667 | 0.92 | SCN9A (0.42) | SCN9AKCNH2SCN5ADRD4UBE2M | |
| SCHEMBL4749784 | 0.92 | SCN9A (0.41) | SCN9AKCNH2SCN5ADRD4UBE2M | |
| SCHEMBL4830469 | 0.86 | SCN9A (0.66) | SCN9AKCNH2SCN5ASLC6A9DRD2 | |
| SCHEMBL4830463 | 0.86 | SCN9A (0.66) | SCN9AKCNH2SCN5ASLC6A9DRD2 | |
| SCHEMBL4841770 | 0.74 | SCN9A (0.80) | SCN9AKCNH2SCN5ADRD2HTR2A | |
| SCHEMBL4830458 | 0.74 | SCN9A (0.80) | SCN9AKCNH2SCN5ADRD2HTR2A | |
| SCHEMBL4830465 | 0.74 | SCN9A (0.80) | SCN9AKCNH2SCN5ADRD2HTR2A | |
| SCHEMBL4750039 | 0.72 | SCN9A (0.66) | SCN9AKCNH2SCN5ADRD4HTR2A | |
| SCHEMBL4750025 | 0.72 | SCN9A (0.65) | SCN9AKCNH2SCN5ADRD4HTR2A | |
| SCHEMBL4749771 | 0.71 | ACACB (0.39) | SCN9AKCNH2SCN5ADRD2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |