Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 8/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.39 |
| ▸ | UBE2M | P61081 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749784 | 0.99 | SCN9A (0.41) | SCN9AKCNH2SCN5ADRD4ACKR3 | |
| SCHEMBL4747544 | 0.92 | SCN9A (0.49) | SCN9AKCNH2SCN5ADRD4DCUN1D1 | |
| SCHEMBL4830463 | 0.80 | SCN9A (0.66) | SCN9AKCNH2SCN5ADRD2HTR2A | |
| SCHEMBL4750039 | 0.80 | SCN9A (0.66) | SCN9AKCNH2SCN5ADRD4HTR2A | |
| SCHEMBL4830469 | 0.80 | SCN9A (0.66) | SCN9AKCNH2SCN5ADRD2HTR2A | |
| SCHEMBL4750025 | 0.79 | SCN9A (0.65) | SCN9AKCNH2SCN5ADRD4HTR2A | |
| SCHEMBL4747610 | 0.78 | SCN9A (0.52) | SCN9AKCNH2SCN5A | |
| SCHEMBL4866628 | 0.77 | DRD2 (0.50) | SCN9AKCNH2SCN5ADRD2HTR2A | |
| SCHEMBL4866636 | 0.77 | DRD2 (0.50) | SCN9AKCNH2SCN5ADRD2HTR2A | |
| SCHEMBL4749771 | 0.76 | ACACB (0.39) | SCN9AKCNH2SCN5ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |