SCHEMBL4747650

SCHEMBL4747650

Cc1ccc(-c2nc(COc3cccc(CN4CCOCC4C(=O)O)c3)c(C)o2)cc1

nearest known ligand 0.60

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PPARG P37231 18/20 0.60
PPARA Q07869 18/20 0.60
CYP2C9 P11712 7/20 0.56
KCNH2 Q12809 7/20 0.56
KDR P35968 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4745066 1.00 PPARG (0.60) PPARGPPARACYP2C9KCNH2KDR
SCHEMBL4748435 0.95 KDR (0.59) PPARGPPARACYP2C9KCNH2KDR
SCHEMBL4747572 0.95 KDR (0.59) PPARGPPARACYP2C9KCNH2KDR
SCHEMBL4746999 0.93 PPARG (0.53) PPARGPPARA
SCHEMBL4743984 0.93 PPARG (0.53) PPARGPPARA
SCHEMBL4747418 0.92 PPARG (0.56) PPARGPPARACYP2C9KCNH2KDR
SCHEMBL4786897 0.92 PPARG (0.51) PPARGPPARACYP2C9KCNH2KDR
SCHEMBL4747182 0.92 PPARG (0.56) PPARGPPARACYP2C9KCNH2KDR
SCHEMBL4748082 0.92 PPARG (0.56) PPARGPPARACYP2C9KCNH2KDR
SCHEMBL4748439 0.90 PPARG (0.58) PPARGPPARACYP2C9KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008117982-A1 HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR INHIBITING LIPID ACCUMULATION CONTAINING SAME CRYSTAL GENOMICS, INC. (KR) 2008-10-02 WO claimed
WO-2008117982-A1 HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR INHIBITING LIPID ACCUMULATION CONTAINING SAME CRYSTAL GENOMICS, INC. (KR) 2008-10-02 WO disclosed