SCHEMBL4748435

SCHEMBL4748435

Cc1oc(-c2ccccc2)nc1COc1cccc(CN2CCOCC2C(=O)O)c1

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KDR P35968 1/20 0.59
PPARG P37231 16/20 0.54
PPARA Q07869 16/20 0.54
CD274 Q9NZQ7 2/20 0.52
CYP2C9 P11712 1/20 0.49
KCNH2 Q12809 1/20 0.49
FFAR1 O14842 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4747572 1.00 KDR (0.59) KDRPPARGPPARACD274CYP2C9
SCHEMBL4747650 0.95 PPARG (0.60) KDRPPARGPPARACYP2C9KCNH2
SCHEMBL4745066 0.95 PPARG (0.60) KDRPPARGPPARACYP2C9KCNH2
SCHEMBL4746593 0.93 KDR (0.57) KDRPPARGPPARACYP2C9KCNH2
SCHEMBL4744645 0.93 PPARG (0.58) PPARGPPARA
SCHEMBL4747325 0.93 PPARG (0.58) PPARGPPARA
SCHEMBL4747182 0.92 PPARG (0.56) KDRPPARGPPARACYP2C9KCNH2
SCHEMBL4748082 0.92 PPARG (0.56) KDRPPARGPPARACYP2C9KCNH2
SCHEMBL4786897 0.92 PPARG (0.51) KDRPPARGPPARACD274CYP2C9
SCHEMBL4744768 0.91 FFAR1 (0.58) KDRPPARGPPARACD274FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008117982-A1 HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR INHIBITING LIPID ACCUMULATION CONTAINING SAME CRYSTAL GENOMICS, INC. (KR) 2008-10-02 WO claimed
WO-2008117982-A1 HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR INHIBITING LIPID ACCUMULATION CONTAINING SAME CRYSTAL GENOMICS, INC. (KR) 2008-10-02 WO disclosed