Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 16/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.54 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496566 | 0.80 | PRMT5 (0.51) | PRMT5KDM4EMAPK1HTTNPSR1 | |
| Hydrochloric Acid SCHEMBL496305 | 0.79 | PRMT5 (0.50) | PRMT5KDM4EMAPK1HTTNPSR1 | |
| SCHEMBL17578645 | 0.77 | CARM1 (0.63) | PRMT5HTTWDR77CARM1 | |
| SCHEMBL30019323 | 0.76 | CARM1 (0.74) | PRMT5HTTWDR77CARM1 | |
| SCHEMBL20042490 | 0.74 | CARM1 (0.71) | PRMT5KDM4EMAPK1HTTNPSR1 | |
| SCHEMBL25910580 | 0.74 | CARM1 (0.71) | PRMT5KDM4EMAPK1HTTNPSR1 | |
| SCHEMBL13875133 | 0.74 | CARM1 (0.71) | PRMT5KDM4EMAPK1HTTNPSR1 | |
| SCHEMBL17813632 | 0.72 | CARM1 (0.68) | PRMT5HTTWDR77CARM1 | |
| SCHEMBL13033223 | 0.72 | PRMT5 (0.78) | PRMT5WDR77 | |
| SCHEMBL21351057 | 0.72 | PRMT5 (0.72) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910317-A1 | 1-AMINO LINKED COMPOUNDS | Eli Lilly and Company (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007015805-A1 | 1-AMINO LINKED COMPOUNDS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |