Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.56 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4838400 | 0.84 | KCNH2 (0.70) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL4838380 | 0.84 | KCNH2 (0.70) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL4839237 | 0.81 | KCNH2 (0.55) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL4839223 | 0.81 | KCNH2 (0.55) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL4838319 | 0.79 | KCNH2 (0.70) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL4838340 | 0.79 | KCNH2 (0.70) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL4842018 | 0.79 | KCNH2 (0.70) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL8075560 | 0.78 | KCNH2 (0.61) | KCNH2SCN9ASCN5AALDH1A1LMNA | |
| SCHEMBL4830463 | 0.78 | SCN9A (0.66) | KCNH2SCN9ASCN5AALDH1A1LMNA | |
| SCHEMBL4830454 | 0.78 | KCNH2 (0.63) | KCNH2SCN9ASCN5AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130322-A1 | NOVEL 5-HETEROCYCLYL-CHROMANE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |