Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.61 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.61 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4842018 | 0.87 | KCNH2 (0.70) | KCNH2SCN9ASCN5ADRD2HTR2A | |
| SCHEMBL4838319 | 0.87 | KCNH2 (0.70) | KCNH2SCN9ASCN5ADRD2HTR2A | |
| SCHEMBL4838340 | 0.87 | KCNH2 (0.70) | KCNH2SCN9ASCN5ADRD2HTR2A | |
| SCHEMBL4839223 | 0.84 | KCNH2 (0.55) | KCNH2SCN9ASCN5ADRD2HTR2A | |
| SCHEMBL4839237 | 0.84 | KCNH2 (0.55) | KCNH2SCN9ASCN5ADRD2HTR2A | |
| SCHEMBL27542741 | 0.84 | KCNH2 (0.68) | KCNH2SCN9ASCN5ADRD2HTR2A | |
| SCHEMBL4837929 | 0.84 | KCNH2 (0.68) | KCNH2SCN9ASCN5ADRD2HTR2A | |
| SCHEMBL8080619 | 0.82 | SCN9A (0.73) | KCNH2SCN9ASCN5ADRD2HTR2A | |
| SCHEMBL8077356 | 0.82 | KCNH2 (0.57) | KCNH2SCN9ASCN5ADRD2HTR2A | |
| SCHEMBL7482232 | 0.81 | DRD4 (0.48) | KCNH2SCN9ASCN5ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025095-A1 | SUBSTITUTED CHROMAN DERIVATIVES | AstraZeneca AB (SE) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999014212-A1 | SUBSTITUTED CHROMAN DERIVATIVES | ASTRAZENECA AB (SE) | 1999-03-25 | — | — | WO | disclosed |