Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 8/20 | 0.64 |
| ▸ | PTGES | O14684 | 1/20 | 0.54 |
| ▸ | ERN1 | O75460 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.46 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.46 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926885 | 0.86 | PDE7A (0.48) | PDE7APTGESERN1GAAPDE7B | |
| SCHEMBL6929731 | 0.85 | GAA (0.69) | PDE7APTGESERN1GAAPDE7B | |
| SCHEMBL6929722 | 0.85 | GAA (0.55) | PDE7APTGESERN1GAAPDE7B | |
| SCHEMBL6927608 | 0.85 | GAA (0.52) | PDE7APTGESERN1GAAPDE7B | |
| SCHEMBL6927792 | 0.85 | ERN1 (0.56) | PDE7APTGESERN1GAAPDE7B | |
| SCHEMBL6922508 | 0.85 | PDE7A (0.55) | PDE7APTGESERN1GAAPDE7B | |
| SCHEMBL6929496 | 0.85 | PDE7A (0.54) | PDE7APTGESERN1GAAPDE7B | |
| SCHEMBL6928500 | 0.82 | PDE7A (0.54) | PDE7APTGESERN1GAAPDE7B | |
| SCHEMBL6929282 | 0.82 | GAA (0.52) | PDE7APTGESERN1GAAPDE7B | |
| SCHEMBL6926325 | 0.82 | GAA (0.58) | PDE7APTGESERN1GAAPDE7B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134354-A1 | TNF-α PRODUCTION INHIBITOR | ARRAY BIOPHARMA, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
| US-4006145-A | CNS DEPRESSANTS, NEUROLEPTICS | HOFFMANN-LA ROCHE INC. (US) | 1977-02-01 | — | — | US | disclosed |
| US-4006144-A | CNS DEPRESSANTS, NEUROLEPTICS | HOFFMANN-LA ROCHE INC. (US) | 1977-02-01 | — | — | US | disclosed |