Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11908044 | 0.86 | PIM1 (0.37) | PIM1PIM3PIM2PRMT5WDR77 | |
| SCHEMBL474985 | 0.82 | CHEK1 (0.46) | PIM1PIM3PIM2CHEK1ACHE | |
| SCHEMBL473806 | 0.80 | CYP2D6 (0.40) | PIM1PIM3PIM2CHEK1 | |
| SCHEMBL473750 | 0.79 | PIM1 (0.40) | PIM1PIM3PIM2 | |
| SCHEMBL474337 | 0.77 | PIM1 (0.45) | PIM1PIM3PIM2CHEK1ACHE | |
| SCHEMBL1560913 | 0.73 | PIM1 (0.41) | PIM1PIM3PIM2CHEK1ACHE | |
| SCHEMBL11907789 | 0.70 | CHEK1 (0.47) | PIM1PIM3PIM2CHEK1ACHE | |
| SCHEMBL11908677 | 0.69 | CHEK1 (0.47) | PIM1PIM3PIM2CHEK1ACHE | |
| SCHEMBL473714 | 0.68 | MKNK1 (0.46) | PIM1PIM3PIM2CHEK1ACHE | |
| SCHEMBL1560881 | 0.67 | CHEK1 (0.44) | PIM1PIM3PIM2CHEK1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411389-A2 | 9H-PYRROLO[2,3-B: 5,4-C']DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109084-A2 | 9H-PYRROLO[2,3-B: 5,4-C'] DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |