Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11908677 | 0.86 | CHEK1 (0.47) | CHEK1ACHEPIM1MAPTMAP4K1 | |
| SCHEMBL11907789 | 0.85 | CHEK1 (0.47) | CHEK1ACHEPIM1MAPTMAP4K1 | |
| SCHEMBL473714 | 0.85 | MKNK1 (0.46) | CHEK1ACHEPIM1MAPTMAP4K1 | |
| SCHEMBL1560881 | 0.84 | CHEK1 (0.44) | CHEK1ACHEPIM1MAPTMAP4K1 | |
| SCHEMBL474870 | 0.82 | PIM1 (0.38) | CHEK1ACHEPIM1PIM3PIM2 | |
| SCHEMBL1560490 | 0.82 | MAPT (0.53) | CHEK1ACHEPIM1MAPTMAP4K1 | |
| SCHEMBL474337 | 0.81 | PIM1 (0.45) | CHEK1ACHEPIM1MAPTPIM3 | |
| SCHEMBL473640 | 0.81 | CHEK1 (0.43) | CHEK1ACHEPIM1MAPTMAP4K1 | |
| SCHEMBL2216343 | 0.81 | PIM1 (0.45) | CHEK1ACHEPIM1MAPTMAP4K1 | |
| SCHEMBL2219568 | 0.81 | ACHE (0.43) | CHEK1ACHEPIM1MAPTMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411389-A2 | 9H-PYRROLO[2,3-B: 5,4-C']DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109084-A2 | 9H-PYRROLO[2,3-B: 5,4-C'] DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |