Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.51 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 5/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748776 | 1.00 | GAA (0.56) | GAAMAPTATMCYP2D6CYP1A2 | |
| SCHEMBL14024383 | 1.00 | GAA (0.56) | GAAMAPTATMCYP2D6CYP1A2 | |
| SCHEMBL14024382 | 0.94 | MAPT (0.60) | GAAMAPTATMCYP2D6CYP1A2 | |
| SCHEMBL4748929 | 0.94 | MAPT (0.60) | GAAMAPTATMCYP2D6CYP1A2 | |
| SCHEMBL4748932 | 0.94 | MAPT (0.60) | GAAMAPTATMCYP2D6CYP1A2 | |
| Citric Acid SCHEMBL25202377 | 0.90 | GAA (0.46) | GAAMAPTATMCYP2D6CYP1A2 | |
| SCHEMBL14024394 | 0.85 | MAPT (0.59) | GAAMAPTATMCYP2D6CYP1A2 | |
| SCHEMBL4752430 | 0.85 | MAPT (0.59) | GAAMAPTATMCYP2D6CYP1A2 | |
| SCHEMBL4752428 | 0.84 | CYP2D6 (0.58) | GAAMAPTATMCYP2D6CYP1A2 | |
| Citric Acid SCHEMBL25210605 | 0.84 | GAA (0.48) | GAAMAPTATMCYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135886-A2 | QUINOLINE DERIVATIVES FOR USE IN THE INHIBITION OF THE GROWTH OF TUMOUR CELLS | UNIVERSITY OF PRETORIA (ZA) | 2008-11-13 | — | — | WO | disclosed |